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Related Experiment Videos

[Biological rhythms and drugs].

S Shibata1

  • 1Department of Pharmacology, School of Human Sciences, Waseda University, Tokorozawa, Japan.

Nihon Shinkei Seishin Yakurigaku Zasshi = Japanese Journal of Psychopharmacology
|June 22, 1999
PubMed
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Daily biological rhythms, governed by internal circadian mechanisms, influence behavior and physiology. Certain drugs can modulate these rhythms, offering potential for maintaining homeostasis.

Area of Science:

  • Chronobiology
  • Molecular biology
  • Neuroscience

Context:

  • Organisms exhibit precise, daily internal changes influencing behavior and social structures.
  • These daily variations are driven by internal circadian mechanisms.
  • The suprachiasmatic nucleus is identified as the central circadian clock in mammals.

Purpose:

  • To review the cellular mechanisms underlying circadian oscillation, entrainment, and output.
  • To explore the expression of clock genes like mPer1 and mPer2 in various tissues.
  • To discuss the influence of drugs on circadian rhythm regulation.

Summary:

  • Circadian rhythms involve rhythm generation, entrainment to light-dark cycles, and clock output.
  • Clock genes (e.g., mPer1, mPer2) are expressed widely, including in the brain and peripheral tissues.

Related Experiment Videos

  • Pharmacological agents like serotonergic drugs, melatonin, lithium, and estrogen can modulate circadian functions.

    • Impact:

    • Drugs can regulate circadian oscillation, entrainment, and output.
    • Central nervous system (CNS) drugs may help maintain physiological homeostasis by acting on biological rhythms.
    • Understanding drug interactions with circadian systems opens avenues for therapeutic interventions.