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[Study on the relationship between PS2 protein expression and prognosis in invasive breast carcinoma]
Objective:
To study the relationship between the expression of PS2 protein and prognosis in the invasive breast cancer (IBC).
Method:
Using LSAB immunohistochemical method, PS2 protein expression in 86 cases of IBC was detected.
Results:
The positive rate of PS2 protein was 66.27% (57/86) in 86 cases of IBC. Under the following 3 conditions, PS2 protein expression levels in the more-than-5-year-survival group (A) were higher than those in the less-than-5-year-survival group (B). (1) In 86 cases of IBC, the expression level was 80.55% (29/36) for Group A, Significantly different from the 56.00% (28/50) of Group B (P < 0.025). (2) In 62 cases of premenopausal patients, the corresponding data were 86.20% (25/29) and 54.54% (18/33) respectively, P < 0.005; whereas in 24 cases of postmenopausal patients, 4/7 and 58.82% (10/17) respectively, P > 0.5. (3) In 62 cases of axillary node positive patients, the expression levels for Groups A and B were 82.35% (14/17) and 55.55% (25/45) respectively, P < 0.05; while in 24 cases of axillary node negative patients, 78.94% (15/19) and (3/5) respectively, P > 0.5.
Conclusions:
These results suggest that the expression of PS2 protein was positively correlated with 5-year-survival in IBC, and could be considered as a prognostic predictor for breast cancer, PS2 protein expression was a useful indicator for endocrine therapy in premenopausal patients. In axillary node positive patients, the expression of PS2 protein was associated with a better prognosis.