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Colchicine poisoning: report of a fatal case with body fluid and post-mortem tissue analysis by high-performance
B Dehon1, J L Chagnon, E Vinner
1Laboratoire de Biochimie et Biologie Moléculaire, Hôpital Calmette, Lille, France.
Biomedical Chromatography : BMC
|June 22, 1999
Abstract:
A case involving a suicide by the ingestion of colchicine tablets is presented. Liquid chromatography has been used to measure the drug level in blood and in post-mortem tissues of the patient (a 42-year-old man). Plasma concentration 24 h after ingestion was 4.5 ng/mL. On autopsy, the kidney showed the highest concentration (396 ng/g). High concentrations were also found in the liver (347 ng/g) and heart (334 ng/g). Low concentrations were detected in the lung (58 ng/g), muscle (10 ng/g) and brain (5 ng/g).