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Involvement of interleukin-2 in analgesia produced by Coriolus versicolor polysaccharide peptides
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|June 22, 1999
Abstract
Aim:
To study the role of interleukin-2 (IL-2) and mediobasal hypothalamus (MBH) in analgesia produced by Coriolus versicolor polysaccharide peptide (PSP).
Methods:
The IL-2 antiserum was injected i.c.v. or i.p. and the MBH was destroyed electrolytically.
Results:
PSP i.g. 1 g.kg-1.d-1 for 6 d increased the pain threshold in tail stimulation-vocalization test in rats. This PSP-produced analgesia was blocked by i.c.v., but not i.p., IL-2 antiserum and disappeared after electrolytic lesion of MBH.
Conclusion:
The analgesia produced by PSP is mediated by IL-2 which is activated by PSP and interacts with IL-2 receptors in the MBH.