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Effect of procainamide on ultrastructure of blood platelet in rabbits
1Department of Electron Microscopy, First Military Medical University, Guangzhou, China.
Zhongguo Yao Li Xue Bao = Acta Pharmacologica Sinica
|June 22, 1999
Abstract
Aim:
To study the effect of procainamide (PA) on the ultrastructure of blood platelets.
Methods:
Arachidonic acid was added to PA-treated platelet-rich plasma to induce platelet aggregation. The 50-nm sections were examined with a transmission electron microscope.
Results:
PA 8.5-136 mumol.L-1 markedly inhibited changes of pseudopods, alpha-granules, dense granules, glycogens, open canalicular system, and dense tubular system.
Conclusion:
PA markedly inhibited the changes of ultrastructure of blood platelet and releasing response.