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Published on: March 29, 2018
Intradermal irritation of dental bleaching agents in rats
C E Gonçalves1, L V Tokano-Ramos, R C Pasccoto
1Departamento de Odontologia, Universidade Estadual de Maringá.
Aim:
To evaluate the irritative potential of three dental bleaching agents (hydrogen oxide, carbopol, and carbamide peroxide).
Methods:
In rats, Evans blue (2.5%, 1 mL.L-1) was injected i.v. and later each test solution was injected intradermally on the back. After the concentration of the dye in the stained skin area was determined by spectrophotometric analysis.
Results:
All the dental bleaching agents caused increase of vascular permeability and the intensity varied with the time.
Conclusion:
Dental bleach agents had a great potential for irritating soft tissues.
