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Alcohol and genetics: new animal models.
1Dept. of Behavioral Neuroscience, Portland Alcohol Research Center, VA Medical Center (R&D12), Portland, OR 97201, USA. browmank@ohsu.edu
Molecular Medicine Today
|June 23, 1999
Summary
Alcoholism has a genetic basis, with multiple genes influencing alcohol sensitivity. Research using animal models is identifying specific genes that could lead to new treatments for alcohol dependence.
Area of Science:
- Neurogenetics
- Pharmacology
- Addiction Research
Background:
- Alcoholism is recognized as a complex trait with significant genetic underpinnings.
- Identifying specific genes contributing to alcoholism has been challenging due to its multigenic nature.
Purpose of the Study:
- To explore the genetic factors contributing to alcoholism.
- To identify specific genes influencing alcohol sensitivity and responses.
- To evaluate the potential of genetic findings in developing pharmacotherapies for alcohol dependence.
Main Methods:
- Utilizing experimental animal models to investigate the genetic components of alcoholism.
- Employing novel genetic manipulations to identify relevant genes.
- Reviewing extensive research on genes potentially influencing alcohol responses.
Main Results:
- Evidence suggests a multigenic trait for alcoholism, with several genes implicated.
- Animal models and genetic studies have provided clues to specific genes involved.
- Research has identified numerous genes that may influence sensitivity to alcohol.
Conclusions:
- Specific genes play a role in alcohol sensitivity and the development of alcoholism.
- Findings from animal models investigating gene function can inform the development of targeted pharmacotherapies.
- Further research into the genetics of alcoholism holds promise for novel treatment strategies.