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[Primary lymphoma of the thyroid with contralateral recurrence--case report]
R Pichler1, M Hatzl-Griesenhofer, H Huber
1Abteilung I für Nuklearmedizin, Allgemeines Krankenhaus Linz, Osterreich.
Wiener Klinische Wochenschrift
|June 23, 1999
Summary
Primary thyroid lymphoma is rare. This case suggests total thyroidectomy may improve long-term remission for thyroid lymphomas, combining surgery, chemotherapy, and radiation therapy.
Area of Science:
- Oncology
- Hematology
- Endocrinology
Background:
- Primary thyroid lymphomas are uncommon, presenting diagnostic and therapeutic challenges.
- Optimal management strategies for thyroid lymphomas remain under discussion.
- Thyroid goiters can rarely mask or be associated with lymphoproliferative disorders.
Observation:
- A 63-year-old female presented with a growing goiter, initially treated with hemi-thyroidectomy.
- Histopathology confirmed a large-cell B-lymphocytic lymphoma involving the thyroid and adjacent lymph nodes.
- The patient experienced a two-year remission after chemotherapy, followed by recurrence in the contralateral thyroid lobe.
Findings:
- Initial treatment included hemi-thyroidectomy, chemotherapy, and involved-field radiation therapy.
- Chemotherapy induced a temporary remission, but the lymphoma recurred in the remaining thyroid lobe.
- Subsequent involved-field radiation therapy achieved long-term disease remission.
Implications:
- This case highlights the potential benefit of total thyroidectomy in managing primary thyroid lymphomas.
- Multimodal therapy, including surgery, chemotherapy, and radiation, is crucial for achieving remission.
- Further research is warranted to establish definitive treatment guidelines for thyroid lymphomas.