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Related Concept Videos

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A thorough health history and physical assessment are essential for identifying cardiovascular disease (CVD) symptoms and distinguishing them from other health issues.
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Coronary Artery Disease I: Introduction01:30

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Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
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Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

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The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
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Peripheral Artery Disease III: Interprofessional Care01:27

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Peripheral Artery Disease (PAD) is characterized by narrowed arteries that diminish blood flow to the extremities. Effective management of PAD requires an interprofessional approach involving various healthcare professionals. The critical aspects of interprofessional care for PAD patients focus on risk factor modification, drug therapy, exercise therapy, nutrition therapy, critical limb ischemia care, and interventional radiology and surgical procedures.The primary treatment goal for PAD...
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Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

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Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
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Psychoneuroimmunology (PNI) is a multidisciplinary field that examines how psychological factors, particularly stress, interact with the immune system and impact physical health. Research in PNI has shown that chronic or traumatic stress can disrupt both the hypothalamic-pituitary-adrenal axis and the sympathetic nervous system. These disruptions contribute to serious health conditions, including cardiovascular diseases.
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Related Experiment Video

Updated: Dec 19, 2025

Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
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Periodontitis and Cardiovascular Diseases. Consensus Report.

M Sanz1, A Marco Del Castillo2, S Jepsen3

  • 1Department of Dental Clinical Specialties and ETEP Research Group, Faculty of Odontology, University Complutense of Madrid, Plaza Ramon y Cajal, Madrid, ES.

Global Heart
|June 4, 2020
PubMed
Summary
This summary is machine-generated.

Severe periodontitis is linked to cardiovascular disease (CVD), a major cause of death in Europe. This review updates evidence on the periodontitis-CVD association, its mechanisms, and treatment impacts.

Keywords:
Periodontitisantitrombotic therapyatherosclerosisbacteremiacardiovascular diseaseschronic inflammationperiodontal therapy

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Area of Science:

  • Periodontology
  • Cardiology
  • Public Health

Background:

  • Cardiovascular disease (CVD) causes 45% of deaths in Europe, with ischemic heart disease, stroke, and hypertension as primary drivers.
  • Periodontitis, a prevalent chronic non-communicable disease (NCD), particularly severe periodontitis affecting 11.2% globally, is the sixth most common human disease.

Purpose of the Study:

  • To update epidemiological evidence on the association between periodontitis and CVD.
  • To review mechanistic links between periodontitis and CVD.
  • To assess the impact of periodontal therapy on cardiovascular outcomes and patient safety.

Main Methods:

  • Review of scientific literature and proceedings from a joint workshop by the European Federation of Periodontology (EFP) and World Heart Federation (WHF).
  • Analysis of emerging scientific information from the past five years.
  • Focus on potential risks and complications of periodontal therapy in patients on anti-thrombotic therapy.

Main Results:

  • Significant associations between periodontitis and CVD are supported by updated epidemiological evidence.
  • Mechanistic links and the impact of periodontal therapy on cardiovascular and surrogate outcomes have been evaluated.
  • Potential risks associated with periodontal therapy in patients on anti-thrombotic medication were identified.

Conclusions:

  • The review provides updated evidence on the periodontitis-CVD link, emphasizing the need for interdisciplinary collaboration.
  • Recommendations are provided for dentists, physicians, and patients regarding managing periodontitis in the context of CVD.
  • Understanding these associations is crucial for public health strategies aimed at reducing NCD burden.