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Experimental side-wall aneurysms: a natural history study
D F Kallmes1, T A Altes, D A Vincent
1Department of Radiology, University of Virginia Health Sciences, Charlottesville 22908, USA. dfk3b@virginia.edu
Neuroradiology
|June 24, 1999
Summary
Canine experimental aneurysms remained open in most cases, showing they are a good model for testing new aneurysm occlusion devices. This study provides control data for future device development.
Area of Science:
- Vascular Surgery
- Biomedical Engineering
- Animal Models
Background:
- Developing effective aneurysm occlusion devices requires reliable control data.
- Understanding the natural history of experimental aneurysms is crucial for validation.
Purpose of the Study:
- To determine the rate of spontaneous thrombosis in canine experimental side-wall aneurysms.
- To establish control data for future studies on aneurysm occlusion devices.
Main Methods:
- Surgically created bilateral common carotid artery vein patch aneurysms in eight mongrel dogs.
- Utilized Duplex Doppler sonography at 14 days and angiography between 30 and 210 days post-creation.
- Monitored aneurysm patency and size.
Main Results:
- Sonography showed 81% (13 of 16) of aneurysms remained patent.
- Angiography confirmed sustained patency in all monitored aneurysms up to 200 days.
- No spontaneous recanalization was observed in initially occluded aneurysms.
Conclusions:
- The canine side-wall aneurysm model is suitable for evaluating aneurysm occlusion devices.
- Control aneurysms in this model demonstrate long-term patency, essential for device testing.