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Blood coagulation parameters in retinal arterial occlusion
A Sagripanti1, A Romani, A Ferretti
1Clinica Medica I, Ospedale S. Chiara, Pisa, Italy.
Summary
Acute retinal ischemia involves increased thrombin generation, indicated by elevated prothrombin fragment 1+2 (F1+2) and thrombin-antithrombin III complex (TAT) levels. These markers decreased after treatment, suggesting thrombin plays a role in retinal arterial occlusion.
Area of Science:
- Ophthalmology
- Hematology
- Vascular Biology
Background:
- Thromboembolism contributes significantly to retinal occlusion, causing severe vision loss.
- Retinal arterial occlusion impacts central or peripheral visual function.
Purpose of the Study:
- To evaluate hemostatic system parameters in patients with acute retinal ischemia.
- To investigate the role of thrombin generation in the pathogenesis of retinal arterial occlusion.
Main Methods:
- Assessed plasma levels of antithrombin III, prothrombin fragment 1+2 (F1+2), thrombin-antithrombin III complex (TAT), and D-dimer in 14 patients with acute retinal arterial occlusion.
- Measurements were taken at diagnosis and during follow-up (3-6 months post-therapy).
Main Results:
- Elevated plasma levels of F1+2, TAT, and D-dimer were observed during the acute phase of retinal ischemia compared to controls.
- F1+2 and TAT levels significantly decreased during follow-up.
- D-dimer levels remained unchanged throughout the study period.
Conclusions:
- Findings suggest accelerated prothrombin conversion to thrombin (indicated by high F1+2) and increased circulating thrombin (indicated by high TAT) during retinal arterial occlusion.
- These results provide evidence for the involvement of increased thrombin generation in acute retinal ischemia.