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Parry-Romberg syndrome with contralateral and ipsilateral extremity involvement
M S Chapman1, J E Peraza, S K Spencer
1Section of Dermatology, Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire 03756, USA.
Journal of Cutaneous Medicine and Surgery
|June 26, 1999
Summary
Parry-Romberg syndrome, a rare condition causing facial atrophy, can also affect limbs. This case highlights unusual contralateral and ipsilateral extremity involvement, expanding understanding of this syndrome.
Area of Science:
- Neurology
- Dermatology
- Rheumatology
Background:
- Parry-Romberg syndrome is a rare disorder characterized by progressive hemifacial atrophy.
- It primarily affects subcutaneous tissues of the scalp and face.
- Extremity involvement is an uncommon manifestation.
Observation:
- This report details a unique case of Parry-Romberg syndrome with both contralateral and ipsilateral extremity involvement.
- The study reviews diagnostic challenges in differentiating it from linear scleroderma en coup de sabre.
- A MEDLINE search identified limited cases of Parry-Romberg syndrome with contralateral extremity involvement.
Findings:
- Contralateral extremity involvement in Parry-Romberg syndrome is exceptionally rare.
- This case may represent the first documented instance of combined contralateral and ipsilateral extremity involvement in the English literature.
Implications:
- This case expands the known spectrum of Parry-Romberg syndrome manifestations.
- It underscores the importance of considering limb involvement in diagnosis.
- Further research is needed to understand the pathophysiology and treatment of this rare presentation.