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Related Experiment Videos

BLAST PRINTS--alternative perspectives on sequence similarity.

W Wright1, P Scordis, T K Attwood

  • 1School of Biological Sciences, Stopford Building, The University of Manchester, Oxford Road, Manchester M13 6PT, UK. wright@biochemistry.ucl.ac.uk

Bioinformatics (Oxford, England)
|June 26, 1999
PubMed
Summary

A new tool integrates BLAST searching with the PRINTS database, enabling rapid protein and DNA sequence analysis. This enhances fingerprint diagnoses and provides novel perspectives for biological queries.

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Area of Science:

  • Bioinformatics
  • Computational Biology
  • Genomics

Background:

  • The PRINTS database contains protein motif information.
  • BLAST is a widely used sequence alignment tool.

Purpose of the Study:

  • To develop an integrated system for searching the PRINTS database using BLAST.
  • To enhance protein and DNA sequence analysis by combining rapid searching with sensitive fingerprint diagnostics.

Main Methods:

  • Implementation of BLAST for PRINTS database searching.
  • Development of an interface for protein and DNA queries.
  • Modification of output with direct links to PRINTS familial discriminators and visualization software.

Main Results:

  • Successful integration of BLAST searching with the PRINTS database.

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  • User-friendly interface for submitting protein and DNA queries.
  • Enhanced output providing links to familial discriminators and visualization tools.

    • Conclusions:

    • The developed server couples BLAST's speed with PRINTS' sensitivity.
    • Provides alternative perspectives for analyzing biological queries.
    • Facilitates rapid and sensitive protein and DNA sequence analysis.