Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Target concentration intervention: beyond Y2K.

N H Holford1

  • 1Department of Pharmacology and Clinical Pharmacology, University of Auckland, Auckland, New Zealand.

British Journal of Clinical Pharmacology
|June 26, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A review of mixed-effects models of tumor growth and effects of anticancer drug treatment used in population analysis.

CPT: pharmacometrics & systems pharmacology·2014
Same author

Drug concentration, binding, and effect in vivo.

Pharmaceutical research·2013
Same author

Vz, the terminal phase volume: time for its terminal phase?

Journal of biopharmaceutical statistics·2002
Same author

Acetaminophen analgesia in children: placebo effect and pain resolution after tonsillectomy.

European journal of clinical pharmacology·2002
Same author

The pharmacokinetics of remifentanil in patients undergoing coronary artery bypass grafting with cardiopulmonary bypass.

Anesthesia and analgesia·2001
Same author

A pharmacokinetic model to predict the PK interaction of L-dopa and benserazide in rats.

Pharmaceutical research·2001
Same journal

N-acetylcysteine for non-paracetamol-induced acute liver failure in children: A systematic review and meta-analysis.

British journal of clinical pharmacology·2026
Same journal

Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis.

British journal of clinical pharmacology·2026
Same journal

Modelling immune gene expression profiles as pharmacodynamic endpoints of antileishmanial treatment.

British journal of clinical pharmacology·2026
Same journal

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone.

British journal of clinical pharmacology·2026
Same journal

Relationship between continuous infusion meropenem PK/PD target attainment and C-reactive protein dynamics in onco-haematologic patients with febrile neutropenia.

British journal of clinical pharmacology·2026
Same journal

UGT1A1 genotype testing for irinotecan: A guideline developed by the UK Centre of Excellence in Regulatory Science and Innovation in Pharmacogenomics (CERSI-PGx).

British journal of clinical pharmacology·2026
See all related articles

Target concentration intervention (TCI) offers a rational approach to dosing, moving beyond traditional therapeutic drug monitoring (TDM). TCI utilizes pharmacokinetic and pharmacodynamic principles for personalized medicine.

Area of Science:

  • Pharmacology
  • Clinical Pharmacy
  • Drug Development

Background:

  • Traditional therapeutic drug monitoring (TDM) relies on a "therapeutic range," which may oversimplify drug effects.
  • Oversimplified pharmacodynamic models in TDM can limit clinical benefits and drug concentration interpretation.

Discussion:

  • Target concentration intervention (TCI) is presented as a superior conceptual strategy to TDM.
  • TCI integrates pharmacokinetic and pharmacodynamic principles for precise dosing.
  • This approach focuses on a target effect and associated concentration for individualized dose adjustments.

Key Insights:

  • TCI enhances rational individual dose decisions by considering both pharmacokinetics and pharmacodynamics.
  • Moving from a "range" to a "target" concentration refines clinical decision-making.

Related Experiment Videos

  • TCI aims to maximize therapeutic benefits and minimize risks through personalized dosing.

    • Outlook:

    • Future research should explore TCI's application across diverse drug classes and patient populations.
    • Wider adoption of TCI could lead to more effective and safer pharmacotherapy.
    • Developing advanced models for TCI will further optimize individualized drug therapy.