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Shortened elastase infusion time in the elastase-induced rat aneurysm model
T Yamaguchi1, M Yokokawa, M Suzuki
1First Department of Surgery, Toyama Medical and Pharmaceutical University, Toyama, 930-0194, Japan.
The Journal of Surgical Research
|June 29, 1999
Summary
Shortening elastase infusion time in rat aneurysm models from 120 to 30 minutes is feasible. This optimization significantly reduces experimental duration and animal mortality rates.
Area of Science:
- Vascular Surgery
- Animal Models
- Aortic Aneurysm Research
Background:
- The elastase-induced rat aneurysm model is crucial for studying abdominal aortic aneurysms (AAAs).
- Optimizing experimental parameters, such as infusion time, can improve model efficiency and reduce animal distress.
Purpose of the Study:
- To determine if elastase infusion time can be reduced in the elastase-induced rat aneurysm model.
- To assess the impact of shortened infusion times on aneurysm development and mortality.
Main Methods:
- Rats received elastase infusions of varying durations (10-120 min) or saline (control).
- Mortality rates were monitored daily.
- Aortic diameter and histology were assessed on day 7 in surviving rats.
Main Results:
- Infusion times of 10, 20, or 30 minutes did not result in mortality.
- A 30-minute elastase infusion created significantly larger aortas compared to 10- and 20-minute infusions.
- Histology revealed significant aortic wall damage in 30-minute and longer infusions.
Conclusions:
- Elastase infusion time in the rat aneurysm model can be safely shortened to 30 minutes.
- Reducing infusion time decreases experimental duration and mortality.
- This optimized model allows for efficient AAA research with reduced animal loss.