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Prothiofos metabolites in human poisoning.
1Health Sciences University of Hokkaido, Nayoro City Hospital, Japan. msakata@hoku-iryo-u.ac.jp
Journal of Toxicology. Clinical Toxicology
|June 29, 1999
Summary
This case report details a prothiofos (Tokuthion) poisoning successfully treated with charcoal hemoperfusion. The study identified key prothiofos metabolites in human plasma and urine, aiding in understanding organophosphate toxicity.
Area of Science:
- Toxicology
- Environmental Health
- Pharmacology
Background:
- Organophosphate pesticides like prothiofos pose significant public health risks.
- Understanding the human metabolism of prothiofos is crucial for effective clinical management of poisoning cases.
Observation:
- A 63-year-old female ingested a large quantity of prothiofos (370 mL of 40% preparation).
- Clinical management included gastric lavage, supportive care, and charcoal hemoperfusion.
- Significantly reduced serum cholinesterase activity (1.3 IU/L) indicated severe poisoning.
Findings:
- Gas chromatography-flame photometry and gas chromatography-mass spectrometry identified prothiofos metabolites in plasma and urine.
- Key metabolites included despropyl prothiofos oxon, des-S-propyl prothiofos, and despropyl prothiofos.
- Elevated levels of 2,4-dichlorophenol and its conjugate were also detected, indicating hydrolysis.
Implications:
- Charcoal hemoperfusion can be an effective treatment for acute prothiofos poisoning.
- Identification of human prothiofos metabolites provides valuable data for toxicokinetic studies.
- The human metabolic pathway for prothiofos differs from that observed in animal models, highlighting species-specific toxicokinetics.