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Blood transfusion-acquired hemoglobin C.

A A Suarez1, J M Polski, B J Grossman

  • 1Department of Pathology, St Louis University, St Louis, MO, USA.

Archives of Pathology & Laboratory Medicine
|July 2, 1999
PubMed
Summary

Confusing lab results can happen after blood transfusions due to passive hemoglobin C transfer. Calculations helped interpret these transfusion-related preanalytic errors, highlighting a rare diagnostic challenge.

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Area of Science:

  • Hematology
  • Clinical Pathology
  • Transfusion Medicine

Background:

  • Blood transfusions can lead to unexpected laboratory findings.
  • Pre-existing hemoglobinopathies in donors may not be detected during screening.
  • Passive transfer of hemoglobin variants is a rare but possible complication.

Observation:

  • A case of spurious hemoglobin C detected in a patient post-red blood cell transfusion is presented.
  • The patient's own hemoglobin levels were normal, indicating passive transfer.
  • This highlights a potential diagnostic pitfall in transfusion medicine.

Findings:

  • Hemoglobin C was passively transferred from donor red blood cells to the recipient.
  • Mathematical calculations comparing expected and measured hemoglobin C levels were crucial for correct interpretation.
  • This case underscores the importance of considering transfusion history in evaluating laboratory results.

Implications:

  • Clinicians must be aware of transfusion-acquired hemoglobinopathies as a cause of abnormal laboratory results.
  • Accurate interpretation requires correlating lab findings with transfusion history.
  • Further investigation into transfusion-related preanalytic errors is warranted to improve patient safety.

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