[Possible molecular and cellular mechanisms of gene expression regulation during learning]

The learning plasticity was shown to be accompanied by a serotonin-induced translocation of Rf 0.58 protein, increasing of the G-protein activity, as well as PKA and c-fos gene expression in Helix. The learning marker Rf 0.58 is absent from the juvenile snails. The AP-1 transcription factors in them cannot be determined or induced with serotonin. The level of CRE factors in juvenile snails was comparable with adult and can be regulated by serotonin. The impossibility of sensitisation and avoidance conditioning reflex in juvenile snails can be explain with the AP-1 factors deficit.