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Choroid plexus papilloma: a clinicopathological study of 23 cases
C Sarkar1, M C Sharma, S Gaikwad
1Department of Pathology, All India Institute of Medical Sciences, New Delhi.
Insights
Choroid plexus papillomas (CPPs) are rare brain tumors, more common in children. This study analyzes 23 cases, highlighting unusual clinical, pathological, and radiological features of these rare tumors.
Area of Science:
- Neuro-oncology
- Pediatric Neurosurgery
- Pathology
Background:
- Choroid plexus papillomas (CPPs) are rare intracranial tumors, comprising <1% in adults but 1.5-4% in children.
- CPPs predominantly occur in the lateral ventricles, with less frequent occurrences in the fourth, third ventricles, and cerebellopontine angle.
Purpose of the Study:
- To analyze 23 cases of choroid plexus papillomas.
- To describe rare clinical, pathological, and radiological features associated with CPPs.
Main Methods:
- Retrospective analysis of 23 CPP cases.
- Review of clinical data, pathological findings, and radiological imaging.
Main Results:
- Detailed description of rare presentations, including cystic appearance with mural nodules.
- Documentation of infrequent occurrences such as bone formation (6 cases) and neuromelanin production (2 cases).
Conclusions:
- This study contributes to the understanding of rare CPP manifestations.
- Highlights the importance of recognizing unusual features for accurate diagnosis and management.
Background:
Choroid plexus papillomas (CPPs) are rare, accounting for less than 1% of all intracranial tumors in adults. However, they are relatively more common in childhood and constitute 1.5 to 4% of intracranial tumors.
Description:
They are most often located in the lateral ventricle, followed by the fourth and third ventricles and, rarely, in the cerebellopontine angle. The radiological appearance of a CPP as a cyst with a mural nodule is a curiosity. Bone formation is rare in CPPs and only 6 cases have been described in the literature. Neuromelanin production is also extremely rare and only 2 cases have been reported to date.
Conclusion:
In the present communication, 23 cases of CPP are analyzed and rare clinical, pathological, and radiological features are described.