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Published on: March 18, 2020
Outcomes Following Definitive Chemoradiation in Locally Advanced Laryngeal and Hypopharyngeal Cancers: Experience
S K Shah1, C Sharma1, N Rathee1
1Department of Radiation Oncology, Tata Medical Center, Kolkata, West Bengal, India.
Aims:
Laryngeal conservation in advanced disease is possible with chemo-radiation (CTRT); however, it is at the expense of significant toxicity. There is sparse data from the Indian subcontinent addressing the same.
Materials And Methods:
A retrospective cohort study of Stage III-IVa/b patients treated between May 2011 and April 2022. We assessed survival outcomes, organ preservation rates, and toxicities.
Results:
300 patients, with a median age of 63 years (57;69), were identified. Median follow-up was 4.1 years (3.5; 4.4). Dysphagia was the most common grade 3 toxicity (119; 40%). The 5-year overall survival (OS) was 61% (55%; 69%). Sitewise, laryngeal cancers (64% (55%; 74%)) fared better than hypopharyngeal cancers (55% (45%; 67%)) with respect to 5-year OS. The larynx preservation rate was 84% (79%; 90%) at 5 years.
Conclusion:
Functional laryngeal preservation is achievable in locally advanced laryngeal and hypopharyngeal cancers with definitive CTRT. Outcomes aligned with established and published data.
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