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Related Experiment Videos

A decrease in regional cerebral blood volume and hematocrit in crossed cerebellar diaschisis.

H Yamauchi1, H Fukuyama, Y Nagahama

  • 1Department of Neurology, Brain Pathophysiology Faculty of Medicine, Kyoto University, Japan. ymuc@kuhp.kyoto-u.ac.jp

Stroke
|July 2, 1999
PubMed
Summary

Crossed cerebellar diaschisis (CCD) reduces total cerebral blood volume (CBV). This condition disproportionately decreases red blood cell volume, leading to lower hematocrit in the affected cerebellar hemisphere.

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Area of Science:

  • Neuroscience
  • Cerebrovascular Physiology

Background:

  • Crossed cerebellar diaschisis (CCD) pathophysiology is not fully understood.
  • Deafferentation-induced metabolic suppression may cause vasoconstriction, impacting cerebral blood volume (CBV).
  • Potential differential effects on red blood cell and plasma flow require investigation.

Purpose of the Study:

  • To determine if CCD decreases total CBV.
  • To investigate differential effects of CCD on cerebral red blood cell volume (CRCV) and cerebral plasma volume (CPV).
  • To assess if CCD alters hematocrit.

Main Methods:

  • Positron emission tomography (PET) used in 7 patients with unilateral supratentorial infarct and CCD.
  • 15O-labeled carbon monoxide tracer for CRCV assessment.

Related Experiment Videos

  • 62Cu-labeled human serum albumin-dithiosemicarbazone tracer for CPV assessment.

    • Main Results:

    • Significantly decreased CRCV, CPV, and total CBV in the cerebellar cortex contralateral to the infarct.
    • CRCV reduction was greater than CPV reduction.
    • Hematocrit was decreased in the contralateral cerebellar cortex.

    Conclusions:

    • CCD may decrease total CBV, potentially due to vasoconstriction from deafferentation-induced metabolic suppression.
    • A more pronounced decrease in CRCV compared to CPV may lead to reduced hematocrit in CCD.
    • Findings elucidate a potential mechanism for altered blood composition in CCD.