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[Young-onset multiple sclerosis].

A Silva1, M J Sá

  • 1Servicio de Neurología, Hospital de São João, Porto, Portugal. angelasilva@mail.telepac.pt

Revista De Neurologia
|July 3, 1999
PubMed
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Multiple sclerosis in young individuals often presents atypically. This study found that age of onset does not predict long-term disability in young-onset multiple sclerosis (MS), suggesting a potentially more favorable prognosis than previously thought.

Area of Science:

  • Neurology
  • Immunology
  • Clinical Medicine

Background:

  • Young onset multiple sclerosis (MS) is rare and can manifest with unusual symptoms and unpredictable outcomes.
  • Understanding the prognostic factors in pediatric and adolescent MS is crucial for patient management.

Purpose of the Study:

  • To evaluate the clinical presentation and disease course in patients with young onset MS.
  • To identify clinical data that may aid in predicting the prognosis of this condition.

Main Methods:

  • Retrospective review of clinical data from 17 patients diagnosed with MS before age 21.
  • Diagnosis adherence to Poser's criteria, incorporating clinical findings, MRI, CSF analysis, and evoked potentials.

Main Results:

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  • The average age of symptom onset was 16.9 years, with a median diagnosis time of four weeks.
  • The majority of patients (76.5%) experienced a relapsing-remitting course, while 23.5% developed secondary progressive MS.
  • A statistically significant correlation was found only between the Expanded Disability Status Scale (EDSS) score and disease duration.

Conclusions:

  • Age at onset did not correlate with final neurological disability, aligning with other research findings.
  • No cases of primary progressive MS were observed in this cohort.
  • Progression in young onset MS is independent of the age of onset and does not invariably lead to a poor prognosis.