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P300 Event-Related Potentials as Cognitive Biomarkers in Neurological and Neuropsychiatric Disorders: A Systematic
Evgenia Gkintoni1,2, Apostolos Vantarakis1, Philippos Gourzis1,2
1Department of Medicine, University of Patras, 26504 Patras, Greece.
The P300 event-related potential is a promising biomarker for neurological and neuropsychiatric disorders. This review highlights its potential for diagnosis, treatment monitoring, and predicting outcomes across various conditions.
Area of Science:
- Neuroscience
- Cognitive Science
- Psychiatry
Background:
- Neurological and neuropsychiatric disorders pose significant global health challenges.
- The P300 event-related potential (ERP), derived from electroencephalography (EEG), is a key measure of cognitive processing.
- P300 latency and amplitude reflect neurocognitive function, making it a potential biomarker for these conditions.
Conclusions:
- P300 shows significant promise as a non-invasive biomarker for cognitive dysfunction in neuropsychiatric disorders.
- Clinical translation is supported by its diagnostic, prognostic, and treatment-monitoring potential.
- Further development in standardization, multi-site validation, and scalable technology is needed for widespread adoption.
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