Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Epidermal cell lineage.

K Turksen1, T C Troy

  • 1Loeb Health Research Institute, Hormones Growth and Development, Department of Cellular and Molecular Medicine, University of Ottawa, ON, Canada. kturksen@lri.ca

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|July 7, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Issues in human embryonic stem cell biology.

Stem cell reviews·2006
Same author

Epidermal lineage.

Methods in molecular biology (Clifton, N.J.)·2002
Same author

ES cell differentiation into the hair follicle lineage in vitro.

Methods in molecular biology (Clifton, N.J.)·2002
Same author

Claudin-6: a novel tight junction molecule is developmentally regulated in mouse embryonic epithelium.

Developmental dynamics : an official publication of the American Association of Anatomists·2001
Same author

In vitro characteristics of early epidermal progenitors isolated from keratin 14 (K14)-deficient mice: insights into the role of keratin 17 in mouse keratinocytes.

Journal of cellular physiology·1999
Same author

Expression and regulation of galectin 3 in rat osteoblastic cells.

Journal of cellular physiology·1996
Same journal

Reply to the discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and metanalysis".

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Discussion of "Efficacy of lactoferrin supplementation in pediatric infections: a systematic review and meta-analysis".

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Does the beta subunit of mitochondrial trifunctional protein modulate monolysocardiolipin acylation to cardiolipin?

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Distinct effects of disease-associated mutations in the proximal C-linker on negatively cooperative binding of cyclic nucleotides to the human HCN4 channel.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

PPP2R2B targets the JAK2-STAT3 signaling pathway to regulate ferroptosis in breast cancer cells.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
Same journal

Suppression of CBP/p300 induces growth inhibition and autophagy of hepatocellular carcinoma cells through regulation of EPHA2 by its super-enhancer acetylation.

Biochemistry and cell biology = Biochimie et biologie cellulaire·2026
See all related articles

Researchers developed a new embryonic stem cell model to study epidermal lineage. This model helps identify factors regulating skin cell differentiation and may offer insights into skin diseases like psoriasis and cancer.

Area of Science:

  • Dermatology and Stem Cell Biology
  • Investigating epidermal homeostasis and differentiation processes.

Background:

  • The epidermis maintains integrity through continuous cell turnover, balancing stem cell self-renewal and differentiation.
  • Understanding epidermal stem cells and lineage commitment is crucial but hindered by a lack of in vitro models and specific reagents.

Purpose of the Study:

  • To analyze factors regulating epidermal lineage using a novel differentiating embryonic stem cell model.
  • To identify genes initiating epidermal progenitor commitment.

Main Methods:

  • Development of a differentiating embryonic stem cell model for studying epidermal lineage.
  • Analysis of factors regulating epidermal lineage and progenitor commitment.

Main Results:

Related Experiment Videos

  • The developed model provides a platform to study early epidermal lineage events.
  • Enables investigation into the regulators of epidermal differentiation and commitment.

Conclusions:

  • The new model offers a significant opportunity to understand epidermal lineage.
  • This research may lead to better insights into hyperproliferative skin diseases like psoriasis and cancer.