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[Uremic hemolytic syndrome. Analysis of 43 cases]
S Mencía Bartolomé1, A Martínez de Azagra, A de Vicente Aymat
1Servicio de Cuidados Intensivos Pediátricos, Hospital del Niño Jesús, Madrid.
Objective:
The purpose of this study was to describe the epidemiological, clinical and evolution features of hemolytic uremic syndrome (HUS).
Patients And Methods:
A retrospective study of 43 cases of HUS during the last 14 years (1984-1998) was performed.
Results:
The mean age of the patients was 3.2 years, the incidence during the summer season was the highest and 39 cases (90%) previously had acute gastroenteritis. All children had acute renal failure, 32 of them (74%) required peritoneal dialysis. Anuria was found in 22 case (51%) and the mean duration was 10.3 days. The most frequent complications were: Hypertension in 21 cases (48%), peritonitis in 9 cases (20%), seizures in 8 patients (16%) and 3 deaths (6%). The mean hospital stay was 14.5 days. After one year of ambulatory control, 76% of the children were completely recovered and only two cases (6%) had chronic renal failure. Seizures associated significantly with a bad prognosis (p < 0.05).
Conclusions:
HUS has a very important morbimortality. Seizures in the acute phase were associated with a bad prognosis. Anuria for more than 7 days and oliguria for more than 15 days were also predictors of a worse prognosis, but this was not significant.