Related Experiment Videos
Urinary tissue factor: a potential marker of disease
B A Lwaleed1, P S Bass, J L Francis
1University Department of Haematology, Southampton University Hospitals, Tremona Road, Southampton SO16 6YD, U.K.
The Journal of Pathology
|July 9, 1999
Summary
Tissue factor (TF) initiates blood clotting and is found in cancer cells and urine (uTF). Measuring uTF may be clinically important for diagnosing kidney disorders and malignancy.
Area of Science:
- Biochemistry
- Oncology
- Nephrology
Background:
- Tissue factor (TF) is the primary initiator of blood coagulation.
- TF plays a role in solid malignancies, especially those involving angiogenesis.
- TF is expressed by cancer cells, macrophages, and monocytes, and is implicated in abnormal coagulation.
Purpose of the Study:
- To investigate the presence and clinical significance of urinary Tissue Factor (uTF).
- To explore the potential of uTF as a biomarker for renal disorders and malignancy.
Main Methods:
- Assaying uTF levels in urine.
- Analyzing the relationship between uTF levels and conditions like malignancy and renal disorders.
Main Results:
- TF is present in urine (uTF) in a lipid-associated form, likely originating from the kidneys.
- uTF levels can be measured cost-effectively.
- uTF levels are not significantly influenced by age, gender, or smoking.
Conclusions:
- Urinary TF (uTF) is a potentially valuable biomarker.
- uTF measurement may offer clinical importance in managing patients with renal disorders and cancer.