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Updated: Aug 1, 2026
15:43
Experimental Generation of Carcinoma-Associated Fibroblasts (CAFs) from Human Mammary Fibroblasts
Published on: October 25, 2011
Giant cell fibroblastoma: an entity or a reactive phenomenon?
V Karabela-Bouropoulou1, G Liapi-Avgeri, H Mahera
1Department of Pathology, Regional State General Hospital KAT, Attiki, Greece.
Pathology, Research and Practice
|July 10, 1999
Summary
Giant Cell Fibroblastoma (GCF) may not be a distinct entity but rather a reactive process. These GCF-like lesions can arise in response to aggressive tumors like dermatofibrosarcoma protuberans.
Area of Science:
- Surgical Pathology
- Oncology
- Dermatopathology
Background:
- Giant Cell Fibroblastoma (GCF) is a rare soft tissue tumor.
- Its exact nature and relationship to other neoplasms remain debated.
- Previous studies have described GCF in various locations and associations.
Purpose of the Study:
- To present histological and immunohistochemical features of four GCF cases.
- To investigate the potential reactive nature of GCF-like lesions.
- To explore the association of GCF with other tumors.
Main Methods:
- Histological examination of tumor samples.
- Immunohistochemical analysis.
- Review of clinical and pathological data.
Main Results:
- Four tumors with GCF patterns were analyzed.
- Three cases were associated with dermatofibrosarcoma protuberans (DFSP).
- One case showed GCF-like foci within a malignant hemangiopericytoma, suggesting a reactive process.
Conclusions:
- GCF-like lesions may represent a reactive change in connective tissue.
- These changes can occur in response to locally aggressive or malignant tumors.
- GCF might not always be a distinct neoplastic entity.
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