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[A paraneoplastic acrosyndrome].

I Delèvaux1, J Cabane, E Le Nechet

  • 1Service de Médecine interne, Hôpital Saint-Antoine, Paris.

Presse Medicale (Paris, France : 1983)
|July 10, 1999
PubMed
Summary
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Paraneoplastic digital ischemia, a rare cancer complication, can manifest as acrosyndrome. Early detection is key, as chemotherapy may improve symptoms.

Area of Science:

  • Oncology
  • Rheumatology
  • Vascular Medicine

Background:

  • Paraneoplastic digital ischemia is a rare complication associated with metastatic adenocarcinomas.
  • This condition can present as acrosyndrome, affecting all four limbs.

Observation:

  • A patient with a history of uterine adenocarcinoma developed digital ischemia and acrosyndrome two years post-remission.
  • Recurrent carcinoma was indicated by a significantly elevated antinuclear antibody titer.
  • Chemotherapy demonstrated efficacy in improving the acrosyndrome symptoms.

Findings:

  • Vasomotor disorders in older individuals without other autoimmune signs may indicate a neoplastic origin.
  • Digital ischemia in this context is likely caused by vasculitis.
  • An elevated antinuclear antibody titer can serve as a supplementary marker for neoplastic etiology.

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Implications:

  • Suggests a paraneoplastic etiology for unexplained vasomotor disorders in older patients.
  • Highlights the potential role of vasculitis in cancer-associated digital ischemia.
  • Emphasizes the diagnostic value of antinuclear antibody titers in suspected paraneoplastic syndromes.