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Adenovirus-mediated gene expression in vivo is enhanced by the antiapoptotic bcl-2 gene
G Bilbao1, J L Contreras, H G Zhang
1Gene Therapy Center, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA.
Journal of Virology
|July 10, 1999
Abstract:
An adenovirus vector encoding the human Bcl-2 gene (hBcl-2) was derived. In vivo expression of hBcl-2 in murine livers enhanced and prolonged adenovirus-mediated gene expression. Furthermore, in the hBcl-2-treated group a significant reduction in the apoptosis induced by the adenovirus vector was observed. Thus, the cytoprotection of the vector-infected cells with antiapoptotic genes appears promising for successful in vivo gene therapy.