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Related Experiment Videos

Fluoridated apatite synthesized using a multi-step fluoride supply system.

M Okazaki1, Y Miake, H Tohda

  • 1Department of Dental Materials Science and Technology, Osaka University, Faculty of Dentistry, Japan.

Biomaterials
|July 14, 1999
PubMed
Summary
This summary is machine-generated.

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Synthesized fluoridated apatite exhibits reduced solubility compared to hydroxyapatite. This novel material, created with a stepwise fluoride supply, shows potential for applications requiring enhanced stability.

Area of Science:

  • Materials Science
  • Biomaterials Chemistry
  • Crystallography

Background:

  • Hydroxyapatite is a key component of teeth and bone.
  • Fluoride incorporation can enhance apatite stability.
  • Controlled synthesis methods are crucial for tailored material properties.

Purpose of the Study:

  • To synthesize fluoridated apatite using a novel 5-step fluoride supply system.
  • To characterize the synthesized fluoridated apatite's structure and properties.
  • To evaluate the solubility of the synthesized fluoridated apatite.

Main Methods:

  • Synthesis of fluoridated apatite at 80°C, pH 7.4, with stepwise fluoride addition.
  • X-ray diffraction (XRD) for structural analysis.
  • Scanning electron microscopy (SEM) and High-resolution transmission electron microscopy (HR-TEM) for morphology and ultrastructure.

Related Experiment Videos

  • Solubility testing in acetate buffer at pH 4.0.

    • Main Results:

    • XRD confirmed an apatitic pattern, with a broader (3 0 0) reflection than homogeneous fluorapatite.
    • SEM revealed needle-like crystals similar to hydroxyapatite and fluorapatite.
    • HR-TEM showed hexagonal cross-sections and structural damage, but no step-like layers.
    • Apparent solubility was significantly lower (12.1 mmol/l) than hydroxyapatite (32.3 mmol/l) and similar to previously synthesized heterogeneous fluoridated apatite (12.5 mmol/l).

    Conclusions:

    • The 5-step fluoride supply system successfully synthesized fluoridated apatite with enhanced stability.
    • The synthesized material demonstrates significantly reduced solubility, comparable to materials with fluoride-rich outer layers.
    • This controlled synthesis approach offers a pathway to develop more stable apatite-based biomaterials.