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Updated: Sep 9, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
(E)-4-{[(4-Meth-oxy-naphthalen-1-yl)methyl-idene]amino}-phenol
Amel Ghames1, Nouara Ziani1,2, Amel Djedouani3,4
1Laboratoire d'électrochimie des matériaux moléculaires et des complexes, (LEMMC), Département de génie des procédés, Université Ferhat Abbas, Sétif 19000, Algeria.
Abstract:
The title Schiff base compound, C18H15NO2, was synthesized via the condensation reaction of 4-hy-droxy aniline and 4-meth-oxy-1-naphthaldehyde in ethanol. The dihedral angle between the phenol ring and the mean plane of the naphthalene ring system is 75.81 (6)°. In the crystal, the mol-ecules are linked by O-H⋯N and C-H⋯O hydrogen bonds, enclosing R 3 3(18) ring motifs and forming zigzag chains propagating along the c-axis direction. The chains are linked via C-H⋯π inter-actions forming slabs lying parallel to the ac plane.
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Alcohols are one of the most important functional groups in organic chemistry. The name of alcohol comes from the hydrocarbon from which it is derived. Alcohols are organic molecules containing the functional hydroxyl or –OH group directly bonded to carbon. Phenols have an OH group directly attached to a benzene ring. While alcohols are colorless, phenol is a white crystalline compound with a characteristic "hospital smell" odor.
As with other organic compounds, alcohols and phenols...
Preparation of Amides
The DCC-promoted synthesis of amides begins with the protonation of DCC by carboxylic acid. The protonation makes it a better acceptor. Next, the addition of carboxylate to the protonated carbodiimide gives a reactive acylating agent.
Subsequently, the amine acts as a nucleophile that attacks the acylating agent to form a tetrahedral intermediate. In the...
2° Amines to N-Nitrosamines: Reaction with NaNO2

