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Related Experiment Videos

Osteosarcomatous differentiation in phyllodes tumors.

S A Silver1, F A Tavassoli

  • 1Department of Gynecologic and Breast Pathology, Armed Forces Institute of Pathology, Washington, DC 20306-6000, USA.

The American Journal of Surgical Pathology
|July 14, 1999
PubMed
Summary
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Phyllodes tumors with osteosarcomatous differentiation are rare and aggressive breast neoplasms. Large tumors (>5 cm) or those with osteoclastic/osteoblastic subtypes indicate a poor prognosis.

Area of Science:

  • Oncology
  • Pathology
  • Breast Cancer Research

Background:

  • Phyllodes tumors are rare fibroepithelial neoplasms of the breast.
  • Osteosarcomatous differentiation within phyllodes tumors is an uncommon finding.
  • Understanding the clinicopathologic features and prognosis of these rare tumors is crucial.

Purpose of the Study:

  • To retrospectively review cases of phyllodes tumors with osteosarcomatous differentiation.
  • To evaluate the prognostic significance of this rare breast neoplasm.
  • To identify clinicopathologic factors associated with patient outcomes.

Main Methods:

  • Retrospective review of 22 cases of phyllodes tumors with osteosarcomatous differentiation.
  • Analysis of patient demographics, tumor characteristics, treatment modalities, and follow-up data.

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  • Univariate and multivariate analyses to assess prognostic factors.

    • Main Results:

    • The study included 22 female patients (mean age, 60 years) with phyllodes tumors showing osteosarcomatous components.
    • Tumor size (mean, 6.4 cm) and osteosarcoma subtype (fibroblastic, osteoclastic, osteoblastic) were evaluated.
    • 52% of patients were alive at median follow-up; 43% developed recurrent or metastatic disease.
    • Metastases were rapidly fatal, with seven deaths within 12 months of detection.

    Conclusions:

    • Phyllodes tumors with osteosarcomatous components are potentially aggressive breast neoplasms.
    • Large tumor size (>5 cm) and osteoclastic or osteoblastic osteosarcoma subtypes are associated with a poorer prognosis.
    • Complete excision without axillary lymph node dissection is recommended for these tumors.