111In-labelled platelets for assessment of thrombogenicity of new haemodialysis vascular access
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Updated: Oct 19, 2026
Microfluidics in Assessing Platelet Function
Published on: November 8, 2024
Using platelet scintigraphy to evaluate early thrombogenicity, we examined 39 new vascular accesses 4 weeks and 3 months after surgery. We found a significant association between platelet deposition and Doppler flow (P < 0.01) and blood pressure (P < 0.01). Compared with arteriovenous fistulae, prosthetic grafts showed significantly higher platelet uptake (after 4 h: 2.4 +/- 1.1 vs 1.2 +/- 1.1 eU, P < 0.05; after 24 h: 2.1 +/- 1.0 vs 0.6 +/- 0.8 eU, P < 0.01) and a higher Doppler flow (1184 +/- 202 vs 609 +/- 342 ml.min-1, P < 0.001). In 8 of 39 accesses, a thrombosis occurred. Accumulation of activity was not related to shunt thrombosis (specificity 61%, sensitivity 71%). We conclude that 111In-platelet scintigraphy is not suitable for the early detection of shunt thrombosis or for identifying patients at risk.
Using platelet scintigraphy to evaluate early thrombogenicity, we examined 39 new vascular accesses 4 weeks and 3 months after surgery. We found a significant association between platelet deposition and Doppler flow (P < 0.01) and blood pressure (P < 0.01). Compared with arteriovenous fistulae, prosthetic grafts showed significantly higher platelet uptake (after 4 h: 2.4 +/- 1.1 vs 1.2 +/- 1.1 eU, P < 0.05; after 24 h: 2.1 +/- 1.0 vs 0.6 +/- 0.8 eU, P < 0.01) and a higher Doppler flow (1184 +/- 202 vs 609 +/- 342 ml.min-1, P < 0.001). In 8 of 39 accesses, a thrombosis occurred. Accumulation of activity was not related to shunt thrombosis (specificity 61%, sensitivity 71%). We conclude that 111In-platelet scintigraphy is not suitable for the early detection of shunt thrombosis or for identifying patients at risk.
