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Gait analysis in the mouse.

K A Clarke1, J Still

  • 1Department of Biomedical Science, University of Sheffield, Western Bank, UK. K.A.Clarke@Sheffield.ac.uk

Physiology & Behavior
|July 15, 1999
PubMed
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This study analyzed mouse locomotion, finding that speed changes are primarily due to stride timing, not length. This consistent mouse gait can aid in evaluating disease states.

Area of Science:

  • Biomechanics
  • Animal Locomotion
  • Mouse Model Studies

Background:

  • Understanding animal gait is crucial for biomechanical research.
  • Previous studies have established rat locomotion data, but mouse gait requires further detailed analysis.
  • The Swiss (Mike Flack--MF1 subtype) mouse is a common model organism.

Purpose of the Study:

  • To analyze the gait parameters of adult Swiss mice during spontaneous walk/trot locomotion.
  • To quantify the relationship between velocity, stride time, and stride length.
  • To establish a baseline for incorporating gait analysis into pathophysiological studies in mice.

Main Methods:

  • Simultaneous video and reaction force analysis were employed.
  • Locomotion was analyzed at velocities ranging from 14-43 cm s(-1).

Related Experiment Videos

  • Forelimb and hindlimb kinematics and kinetics were compared.

    • Main Results:

    • No significant sex-based differences in gait were observed.
    • Velocity adjustments were mainly driven by stride time reduction (>70%) rather than stride length increase (<30%).
    • Peak vertical reaction force increased with decreasing stance time, with forelimbs showing slightly higher forces than hindlimbs.

    Conclusions:

    • The adult Swiss mouse exhibits a consistent and quantifiable gait.
    • Gait parameters are primarily modulated by stride time adjustments.
    • This research supports the integration of locomotor assessment into the evaluation of mouse models for various pathophysiological conditions.