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Flumazenil in children after esophagogastroduodenoscopy

J M Peters1, V Tolia, P Simpson

  • 1Division of Pediatric Gastroenterology, Children's Hospital of Michigan, Wayne State University School of Medicine, Detroit, 48201, USA.

The American Journal of Gastroenterology
|July 16, 1999
PubMed

Insights

Flumazenil, a benzodiazepine antagonist, was tested for its ability to speed recovery after pediatric esophagogastroduodenoscopy. While well-tolerated in children over six, it did not significantly shorten recovery times compared to placebo.

Area of Science:

  • Pediatric Gastroenterology
  • Pharmacology
  • Sedation Management

Background:

  • Conscious sedation with benzodiazepines like diazepam is common for pediatric upper endoscopy.
  • Assessing recovery times and the potential benefits of reversal agents is crucial for patient care.

Purpose of the Study:

  • To determine if routine flumazenil administration shortens recovery times post-esophagogastroduodenoscopy in pediatric patients.
  • To evaluate the safety and efficacy of flumazenil as a reversal agent in this setting.

Main Methods:

  • A double-blind, placebo-controlled study involving 29 children (age 6-18) undergoing esophagogastroduodenoscopy.
  • Patients received either flumazenil or normal saline placebo post-procedure.
  • Alertness was assessed using the Observer's Assessment of Alertness/Sedation Scale.

Main Results:

  • 54% of patients receiving flumazenil and 30% of placebo patients achieved full alertness within 10 minutes.
  • This difference in recovery time was not statistically significant (p > 0.45).
  • No significant side effects or resedation were observed with flumazenil.

Conclusions:

  • Single-dose flumazenil is safe and well-tolerated in children over six years old.
  • Routine use of flumazenil after pediatric esophagogastroduodenoscopy offers questionable benefit for shortening recovery time.
Abstract

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