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Pediatric angioedema: ten years' experience.

U K Shah1, I N Jacobs

  • 1Division of Pediatric Otolaryngology, Children's Hospital of Philadelphia, and the University of Pennsylvania School of Medicine, 19104-4399, USA. shah@email.chop.edu

Archives of Otolaryngology--Head & Neck Surgery
|July 16, 1999
PubMed
Summary

Pediatric angioedema, often affecting the face, differs from adult cases. Prompt treatment with corticosteroids, antihistamines, or epinephrine can lead to rapid recovery in children.

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Area of Science:

  • Pediatrics
  • Immunology
  • Emergency Medicine

Background:

  • Angioedema is a rare but potentially severe condition involving swelling.
  • Understanding pediatric angioedema is crucial due to potential differences from adult presentations.

Purpose of the Study:

  • To investigate the causes, clinical presentation, and management strategies for pediatric angioedema.
  • To compare pediatric angioedema characteristics with those observed in adults.

Main Methods:

  • Retrospective review of 10 hospitalized children diagnosed with angioedema between 1987 and 1997.
  • Analysis of patient demographics, symptom presentation, identified causes, treatments, and clinical outcomes.

Main Results:

  • The study included 7 boys and 3 girls with a mean age of 7.7 years, predominantly experiencing facial swelling.

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  • Common causes included food (40%), insect bites (30%), and infections (20%).
  • All patients received pharmacological treatment, with no need for intubation or intensive care unit (ICU) admission for most.

    • Conclusions:

    • Pediatric angioedema presents with distinct causes and manifestations compared to adults.
    • Early and appropriate medical intervention, including corticosteroids, antihistamines, and epinephrine, ensures rapid resolution.
    • Current management protocols for adults require modification for effective pediatric angioedema treatment.