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Thiazole-derived potent, highly bioavailable short duration growth hormone secretagogues

L Yang¹, G Morriello, K Leung

¹Merck Research Laboratories, Rahway, NJ 07065, USA.

Bioorganic & Medicinal Chemistry Letters

|July 16, 1999

Abstract:

Replacement of the phenyl in 3 with a 2-pyridyl or 4-thiazolyl group resulted in increased potency in the rat pituitary cell GH release assay and in beagles.

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