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Interaction of 4,4'-dithiodipyridine with Cys(458) triggers disassembly of GroEL

E Bochkareva1, M Safro, A Girshovich

  • 1Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel.

The Journal of Biological Chemistry
|July 20, 1999
PubMed

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Protein Modifications in the RER

Modification of secretory and transmembrane proteins entering the rough ER begins in the ER lumen. These modifications aid in protein folding and stabilize the acquired tertiary structure. Protein modifications in the rough ER co-occur at different stages of protein folding.
Broadly, these modifications can be categorized into four main categories — glycosylation, formation of disulfide bonds, assembly of protein subunits, and specific proteolytic cleavages like removal of signal sequences.