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Modern applications of analytical ultracentrifugation
1Department of Biochemistry and Molecular Biology, University of New Hampshire, Durham 03824-3544, USA. Tom.Laue@unh.edu
Annual Review of Biophysics and Biomolecular Structure
|July 20, 1999
Abstract:
Analytical ultracentrifugation is a classical method of biochemistry and molecular biology. Because it is a primary technique, sedimentation can provide first-principle hydrodynamic and first-principle thermodynamic information for nearly any molecule, in a wide range of solvents and over a wide range of solute concentrations. For many questions, it is the technique of choice. This review stresses what information is available from analytical ultracentrifugation and how that information is being extracted and used in contemporary applications.