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Related Experiment Videos

Hypericum perforatum extracts as potential antidepressants.

B Vitiello1

  • 1National Institute of Mental Health, Bethesda, MD, USA. bvitiell@nih.gov

The Journal of Pharmacy and Pharmacology
|July 20, 1999
PubMed
Summary
This summary is machine-generated.

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St. John

Area of Science:

  • Pharmacology and Psychiatry
  • Herbal Medicine Research

Background:

  • Hypericum perforatum (St. John's Wort) has a long history of use for depression in Europe.
  • It is now widely available in the USA as a dietary supplement for mood enhancement.

Purpose of the Study:

  • To critically review existing clinical data on Hypericum perforatum for depression.
  • To present plans for future research to clarify its efficacy and safety.

Main Methods:

  • Systematic review and critical analysis of controlled clinical studies.
  • Evaluation of data comparing Hypericum perforatum to placebo and established antidepressants.

Main Results:

  • Some studies suggest Hypericum perforatum is superior to placebo and comparable to conventional antidepressants.

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  • Existing data have limitations that warrant caution.

    • Conclusions:

    • While promising, current evidence requires further rigorous research.
    • Hypericum perforatum extracts are not yet established antidepressants.
    • More research is needed before widespread acceptance into pharmacopoeias.