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[Extensive eosinophilic pulmonary infiltrates in a depressive patient treated with maprotiline]
R Gaudenz1, K Hartmann, W H Reinhart
1Medizinische Klinik, Rätisches Kantons- und Regionalspital, Chur.
Abstract:
A 74 year old man developed progressive dyspnea under treatment with the tetracyclic antidepressant maprotiline for three months. A chest x-ray revealed extended pulmonary infiltrates. Marked eosinophilia of the periperal blood was found (up to 2300/microliter). Rapid clinical and radiological improvement was observed solely by withholding the drug. The eosinophil count retourned to normal within a few weeks. The possible pathogenesis is discussed and the literature reviewed.
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