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Plasma concentrations of disodium cromoglycate after various inhalation methods in healthy subjects
1Department of Paediatrics, Hiroshima University School of Medicine, Hiroshima, Japan.
Aims:
To compare the plasma concentrations of disodium cromoglycate (DSCG) following various inhalation procedures in healthy volunteers.
Methods:
Nine healthy subjects inhaled 2 mg of aerosol, 20 mg of nebuliser solution only, 20 mg of nebuliser solution mixed with isotonic saline, or 20 mg of nebuliser solution mixed with saline and procaterol, a beta2-adenoceptor agonist, on separate occasions 2-3 weeks apart. Plasma concentrations of DSCG were determined by high-performance liquid chromatography (h.p.l.c.).
Results:
The peak plasma concentrations of DSCG were 1.5+/-0.7 (range 0.4-2.4) ng ml-1 in the aerosol group, 8.8+/-6.2 (range 5.3-19.9) ng ml-1 in the nebuliser solution only group, 17.2+/-16.3 (range 5.0-38.6) ng ml-1 in the nebuliser solution plus isotonic saline group, and 24.5+/-11. 9 (range 10.2-44.9) ng ml-1 in the nebuliser solution plus saline and procaterol group. Thus subjects who used the nebuliser had markedly higher plasma concentrations of DSCG than subjects who used the aerosol inhaler.
Conclusions:
These findings may have important implications for the evaluation of inhalation treatment with DSCG for bronchial asthma.