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[Moxidectin poisoning in a foal?].

L S Goehring1, M M Sloet van Oldruitenborgh-Oosterbaan

  • 1Hoofdafdeling Gezondheidszorg Paard, discipline Inwendige Ziekten, Faculteit der Diergeneeskunde, Universiteit Utrecht.

Tijdschrift Voor Diergeneeskunde
|July 27, 1999
PubMed
Summary
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Moxidectin overdose in a foal caused severe central nervous depression, hypothermia, and bradycardia. Surgical intervention for a ruptured bladder was unsuccessful, leading to sepsis and death, highlighting moxidectin

Area of Science:

  • Veterinary Neurology
  • Toxicology
  • Equine Medicine

Background:

  • Moxidectin, a milbemycin anthelmintic, acts via gamma-aminobutyric acid (GABA) stimulation.
  • Overdose can lead to significant adverse effects in animals.

Observation:

  • A 2-day-old foal presented with coma, hypothermia, bradycardia, and hypoventilation following suspected moxidectin overdose.
  • Clinical signs suggested a ruptured bladder and aspiration pneumonia.
  • Transabdominal ultrasound confirmed bladder rupture.

Findings:

  • The foal's clinical presentation is consistent with moxidectin toxicity.
  • GABAergic effects explain central nervous depression, hypothermia, bradycardia, hypoventilation, and paralytic ileus.
  • Unexpected dyssynergia was observed, likely due to central nervous system effects.

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Implications:

  • This case underscores the potential for severe neurological and physiological consequences of moxidectin overdose in foals.
  • Highlights the importance of accurate dosing and monitoring for adverse effects.
  • Suggests central nervous system involvement in moxidectin-induced dyssynergia.