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Ticlopidine-induced prolonged cholestasis: a case report.

P Amaro1, A Nunes, F Maçôas

  • 1Department of Gastroenterology, Coimbra University Hospital, Portugal.

European Journal of Gastroenterology & Hepatology
|July 27, 1999
PubMed
Summary

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Ticlopidine can cause prolonged cholestasis, a severe liver condition. This case highlights the importance of considering drug-induced liver injury, even when rare.

Area of Science:

  • Hepatology
  • Clinical Pharmacology

Background:

  • Ticlopidine is an antiplatelet medication.
  • Drug-induced liver injury (DILI) encompasses a range of hepatic pathologies.
  • Prolonged cholestasis is a rare but serious form of DILI.

Observation:

  • A 60-year-old male developed jaundice, pruritus, and abdominal pain three months after initiating ticlopidine.
  • Biliary obstruction and other causes of intrahepatic cholestasis were ruled out.
  • Liver biopsy revealed cholestatic hepatitis with bile duct damage.

Findings:

  • The patient experienced a severe and protracted course of cholestasis.
  • Symptoms resolved five months after discontinuing ticlopidine.
  • Abnormal liver function tests indicative of anicteric cholestasis persisted for over a year.

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Implications:

  • This case represents one of the few documented instances of ticlopidine-induced prolonged cholestasis.
  • It underscores the need for vigilance in diagnosing DILI, particularly with prolonged cholestatic syndromes.
  • Further research into the mechanisms and risk factors for ticlopidine hepatotoxicity is warranted.