Acidic antiinflammatory agents--correlations of some physical, pharmacological and clinical data

Fifteen acidic antiinflammatory agents, for which some clinical data have previously been published, have been examined for their potency in the carrageenan-induced rat foot edema test, and for their acidity (pKa) and partition coefficients. Published serum half-life data and daily clinical (anti-arthritic) dose have been tabulated for these drugs and correlations between these various parameters are discussed. The rat foot edema carrageenan test has proved to be a fairly reliable predictor of clinical dose for most acidic antiinflammatory agents of moderate serum half-life.