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Updated: Aug 5, 2026
Corneal Confocal Microscopy: A Novel Non-invasive Technique to Quantify Small Fibre Pathology in Peripheral Neuropathies
Published on: January 3, 2011
Confocal microscopy in posterior polymorphous corneal dystrophy
A G Chiou1, S C Kaufman, R W Beuerman
1Louisiana State University Eye Center, New Orleans, LA 70112-2234, USA.
Purpose:
To report the distinguishing characteristics of posterior polymorphous corneal dystrophy (PPMD) using confocal microscopy.
Material And Methods:
Two consecutive patients with PPMD were prospectively examined using a white-light tandem scanning confocal microscope with a 24x/0.60 contact objective.
Results:
At the level of Descement's membrane, roundish hyporeflective images were found in 1 patient. In the other patient, hyporeflective bands were detected. In both patients, patchy hyperreflective areas were identified.
Conclusion:
Confocal microscopy may allow diagnosis of PPMD by demonstrating the alterations in Descement's membrane. This technique is especially valuable in cases of endothelial decompensation, where slit-lamp and specular microscopy may fail to demonstrate changes in Descement's membrane.
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