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Related Experiment Videos

Confocal microscopy in lattice corneal dystrophy.

A G Chiou1, R W Beuerman, S C Kaufman

  • 1Cornea & Refractive Surgery, Department of Ophthalmology, University of Lausanne, Switzerland. Wonderchiou@Rocketmail.com

Graefe'S Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie
|August 25, 1999
PubMed
Summary

White-light confocal microscopy revealed characteristic linear structures in lattice corneal dystrophy. This imaging technique helps differentiate it from fungal infections in the cornea.

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Area of Science:

  • Ophthalmology
  • Corneal Diseases
  • Microscopy

Background:

  • Lattice corneal dystrophy is a hereditary condition affecting the cornea.
  • Accurate diagnosis is crucial for appropriate management and preventing vision loss.
  • White-light confocal microscopy offers a non-invasive method for in vivo corneal imaging.

Observation:

  • Two patients with lattice corneal dystrophy underwent in vivo white-light tandem-scanning confocal microscopy.
  • Corneal buttons from one patient were histologically examined and compared with confocal microscopy findings.
  • The non-seeing eye of a monocular patient was also examined.

Findings:

  • Confocal microscopy visualized linear and branching structures within the corneal stroma.
  • These structures exhibited variable reflectivity and indistinct borders.

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  • Measured dimensions of the linear opacities ranged from 40-80 micrometers.

    • Implications:

    • Confocal microscopy provides characteristic visual evidence of lattice corneal dystrophy.
    • This imaging modality can aid in distinguishing lattice corneal dystrophy from microbial keratitis, such as fungal infections.
    • It may improve diagnostic accuracy and guide treatment decisions in corneal dystrophies.