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Phlegmonous inflammation of gastrointestinal tract autopsy study of three cases
N Kakkar1, R K Vasishta, A K Banerjee
1Department of Histopathology, Postgraduate Institute of Medical Education and Research, Chandigarh, India.
Insights
Phlegmonous inflammation of the gastrointestinal tract, a serious condition, was observed in three necropsy cases. Underlying health issues like liver disease and Budd Chiari syndrome predisposed patients to this inflammation.
Area of Science:
- Gastroenterology
- Pathology
- Infectious Diseases
Background:
- Phlegmonous inflammation of the gastrointestinal tract is a severe, diffuse inflammation.
- Predisposing factors are crucial in the development of this condition.
- Necropsy provides valuable insights into the pathology of gastrointestinal diseases.
Observation:
- Three cases of phlegmonous gastrointestinal inflammation were identified during necropsy.
- Case 1: Chronic alcoholism with hepatic necrosis (HbsAg, HbcAg positive).
- Case 2: Indian Childhood Cirrhosis.
- Case 3: Acute on chronic Budd Chiari syndrome.
- Inflammation affected the large intestine in Cases 1 and 3.
- Inflammation involved the stomach and large intestine in Case 2.
Findings:
- Blood cultures revealed Staphylococcus aureus in Case 1.
- Gram-negative organisms were identified in blood cultures from Case 2.
- The underlying conditions significantly contributed to the phlegmonous inflammation.
Implications:
- Understanding predisposing factors is key for preventing phlegmonous gastrointestinal inflammation.
- Early identification and management of liver disease and vascular disorders may reduce risk.
- Microbial identification aids in understanding pathogenesis and potential treatment strategies.
Abstract:
Three cases of Phlegmonous inflammation of gastrointestinal tract detected at necropsy are described. Predisposing factors were seen in all three cases. These were chronic alcoholism with submissive hepatic necrosis (HbsAg and HbcAg positive) in Case 1, Indian Childhood cirrhosis in Case 2 and acute on chronic Budd Chiari syndrome in Case 3. In case 1 and 3 the inflammation was limited to the large intestine where as in Case 2 it was seen both in the stomach and large intestine. In two of the three cases blood culture grew Staphylococcus aureus (Case 1) and gram negative organisms (Case 2).