Meissnerian neurofibroma: A rare histological variant of neurofibroma

Meissnerian neurofibroma is an extremely rare histological variant of neurofibroma, with less than ten reported cases of prominent differentiation toward pseudo-meissnerian bodies in the literature. The presence of focal or sparsely scattered pseudo-meissnerian bodies in neurofibromas is well documented in diffuse and plexiform types. It is also seen in various peripheral nerve sheath tumors, including schwannomas, as well as in congenital melanocytic nevi and neural crest hamartomas. The complete excision of the lesion is considered to be curative. We hereby present a rare case of prominent meissnerian differentiation in neurofibroma in a 26-year-old female.