[Post-vaccination immunity after allogenic and autologous bone marrow transplantation]

In the submitted review the author describes time correlation's of reconstitution of immunity during the post-transplantation period in patients after autologous and allogeneic bone marrow transplantations. The authors presents values of different immunological parameters incl. functional examinations of immunity by the method of blastic lymphocyte transformation after stimulation with mitogens and vaccination antigens during the post-transplantation period. She also evaluates mechanisms involved in this process. An illustrative idea on the character and degree of affection of immunity mechanisms after bone marrow transplantation is provided by the state of postvaccination immunity after immunization made before the disease and bone marrow transplantation. The titres of postvaccination antibodies after a 1-4-year interval following bone marrow transplantation gradually drop to low or zero values. The author emphasises therefore the necessity of revaccination of patients with killed vaccines against tetanus, diphtheria, poliovirus and pneumococcal, meningococcal and haemophil infection during the post-transplantation period. Recommended vaccination patterns are also presented.